Hello everyone!
My name is Shanmayee, and I am a rising senior majoring in Biological Sciences with a minor in Chemistry and Studio Arts, and I am also pursuing a certificate in the Conceptual Foundations of Medicine. I am super excited to be part of the Health Sciences Fellowship program this summer and am looking forward to learning about everyone’s projects. My research is focused on cell and molecular biology, specifically focusing on investigating the health and function of mitochondria.
More specifically, my project investigates the role of Ganglioside-induced differentiation-associated protein 1 (GDAP1) in regulating mitochondrial calcium levels, focusing on its protective mechanisms during oxidative stress. Under the mentorship of Dr. Kirill Kiselyov in the Department of Biological Sciences, I aim to explore how GDAP1 influences mitochondrial calcium homeostasis under conditions induced by tert-butyl hydroperoxide (tBHP), a chemical known to generate reactive oxygen species (ROS) that mimic oxidative stress. This research is pivotal as mitochondrial dysfunction and disrupted calcium signaling are implicated in neurodegenerative diseases like Alzheimer’s and Parkinson’s. By exploring GDAP1’s function, we are trying to uncover new insights into disease mechanisms and potential therapeutic strategies.
My ultimate goal is to attend medical school and pursue a career in medicine, driven by a passion for understanding disease progression and cellular components. While I am not currently on the MD/PhD path, research plays an important role in my journey toward becoming a physician. This summer fellowship presents an opportunity for me to delve into the intricacies of mitochondrial biology and oxidative stress. By gaining hands-on experience in research techniques like cell culture and microscopy, I aim to broaden my scientific knowledge and contribute meaningfully to our understanding of neurodegenerative diseases. This experience will not only prepare me for the rigors of medical school but also reinforce my commitment to bridging the gap between research discoveries and clinical applications in patient care.
Outside of my academic and research life, I love swimming, which has been a personal hobby and a way for me to connect with others. This summer, I’m excited to be part of the Pitt Kid’s summer program as a lead instructor, teaching swimming techniques to children aged 5-7. It’s a truly rewarding experience to witness the kids’ progress and enthusiasm in the water.
I am super excited for this summer and what it will bring, both in research discoveries and memorable moments with the Pitt Kid’s summer program.